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A 45 year old man attends the urgent care centre with a 4 hour history of abdominal pain, diarrhoea, fever and rigors. He is currently receiving chemotherapy for acute myeloid leukaemia. On examination, his temperature is 39.8 °C, his heart rate is 133 beats per minute, his respiratory rate is 26 breaths per minute, his oxygen saturations are 98% on air and his blood pressure is 88/48 mmHg.

Based on the likely diagnosis, what is the most appropriate initial management step?

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