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Mrs Salako is 25 years old and is ten weeks pregnant with her first baby. Booking bloods identified she has sickle cell trait (Hb AS). She is otherwise fit and well, works full-time as a nursery teacher and does not smoke. Her husband is known to have Sickle cell disease (HbSS). She is distressed today and would like to discuss what the chances are that her baby will be affected and is also wondering if having sickle trait will affect her whilst pregnant.

Which one of the following options is correct regarding Sickle cell disease and it’s inheritance?

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