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A 45 year old man attends the urgent care centre with a 4 hour history of abdominal pain, diarrhoea, fever and rigors. He is currently receiving chemotherapy for acute myeloid leukaemia. On examination, his temperature is 39.8oC, his heart rate is 133 beats per minute, his respiratory rate is 26 breaths per minute, his oxygen saturations are 98% on air and his blood pressure is 88/48 mmHg.

Based on the likely diagnosis, what is the most appropriate initial management step?

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